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Quarantine is the first episode of the fifeteenth season.
- Emily (cameo)
- Unnamed Humans
- James (cameo)
- Henry (cameo)
- Sir Topham Hatt
- Troublesome Trucks (not named, do not speak)
- Lorry 1
- The Spiteful Brakevan (cameo)
- Some Workman
- Rocky (does not speak)
- Arthur (does not speak)
- Farmer MColl (not named)
- This episode is base off the TUGS episode of the first same name and the Stories of Sodor episode of the second same name.
- Lady's first appearence since Lady the Lost Engine.
- Lady's first appearence in an episode.
- Farmer MColl's first appearence since the first season episode, Thomas' 4th of July and his first speaking role to date.